Lyme Disease Diagnostic Challenges


The CDC recommends a clinical diagnosis, including symptoms and exposure to infected ticks.

The FDA Public Health Advisory dated July 7,  1997 states, “Physicians are advised to base diagnosis on history (including symptoms and exposure to the tick vector), physical findings and laboratory data other than the anti Bb blood results.”

Lyme disease must not be ruled out solely on the basis of a negative test result.

The results of commonly marketed antibody tests to detect Borrelia burgdorferi (anti Bb), the organism that causes Lyme Disease, may be misinterpreted.

Not only can Lyme disease be incorrectly diagnosed as other conditions, it can also occur concurrently with other conditions or be diagnosed incorrectly.

Therefore, patients who suspect Lyme disease must have a full clinical evaluation by a knowledgeable, “Lyme Literate” physician.

While a “bulls-eye” rash is diagnostic for Lyme disease, the types of rashes seen in Lyme disease vary greatly.

A significant number of patients do not recall any rash or tick-bite.  Bites may go unnoticed, especially in the spring, when ticks are small.

Transmission may also occur without a bite, (i.e. placental transmission, blood transfusion, etc.)

Symptoms can appear quickly or develop over time.

Misdiagnosis Issues:

“Lyme disease is the latest great imitator and should be considered in the differential diagnosis of MS, ALS, seizure and other neurologic conditions, as well as arthritis, CFS, Gulf war syndrome, ADHD, hypochondriasis, fibromyalgia, somatization disorder and patients with various difficult-to-diagnose multi-system syndromes.” International Lyme and Associated Diseases Society (ILADS),

Some Possible Infections Transmitted by Ticks:

Lyme Disease                                                                   Babesiosis*
Ehrlichiosis*                                                                    Bartonellosis
Rocky Mountain Spotted Fever*                            Tularemia

*prevalent in Southeastern  Pennsylvania.

The presence of multiple infections tends to further
complicate diagnosis and treatment.



Early in the illness Lyme disease can be confused with the flu, but as the disease progresses it can lead to cardiac, musculoskeletal, neurological, and/or other system involvement.

Patients with chronic Lyme disease often experience severe headaches, fatigue, pain, insomnia, and memory problems.

Chronic Lyme disease can render people completely disabled. For a comprehensive list of symptoms, click here.


Lyme disease is treated with antibiotics, either orally or intravenously.

Prompt and thorough treatment early in the illness is the most effective method for preventing a persistent, disabling condition.

There is no known cure for chronic Lyme disease, and its treatment is surrounded by much controversy.

Many patients find improvements when treated long term, either for Lyme disease bacterial infection and/or for the presence of co-infection.

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